That’s why the first half of Lost Highway is so brooding and mysterious. It pushes up against the limits of what can be seen and said. So much is hinted at, and so little is shown. Even the event upon which the whole film turns, Fred’s apparent murder of Renee, does not take place on screen. We see what comes before, and what comes after. But we do not–cannot–see the act itself. It is missing from the body of the film, just as it is missing from Fred’s own consciousness. The murder drives the story, but it stands apart from the story. It is like an intrusion from another world.
– Shaviro, “Lost Highway“